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成骨相關(guān)轉(zhuǎn)錄因子抗體
  • 產(chǎn)品貨號(hào)：
    BN42187R
  • 中文名稱：
    成骨相關(guān)轉(zhuǎn)錄因子抗體
  • 英文名稱：
    Rabbit anti-Osterix Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN42187R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN42187R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Osterix
中文名稱成骨相關(guān)轉(zhuǎn)錄因子抗體
別    名Osterix; MGC126598; Osx; Sp 7; Sp7; Sp7 transcription factor; Transcription factor Sp7; Zinc finger protein osterix; SP7_HUMAN.  
研究領(lǐng)域細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Osterix:331-431/431 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

Function:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).

Subunit:
Interacts with NO66; the interaction is direct and inhibits transcription activator activity.

Subcellular Location:
Nucleus.

Tissue Specificity:
Osteoblast/chondrocyte specific.

DISEASE:
Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

SWISS:
Q8TDD2

Gene ID:
121340

Database links:

Entrez Gene: 121340 Human

Entrez Gene: 170574 Mouse

Entrez Gene: 300260 Rat

Omim: 606633 Human

SwissProt: Q8TDD2 Human

SwissProt: Q5RM08 Mouse

SwissProt: Q8VI67 Mouse

SwissProt: Q6IMK1 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Osterix成骨相關(guān)轉(zhuǎn)錄因子是一種具有鋅指基序結(jié)構(gòu)域的轉(zhuǎn)錄因子，在體內(nèi)的表達(dá)對(duì)成骨細(xì)胞具有特異性。該蛋白只在發(fā)育的骨組織中特異性表達(dá)，是成骨細(xì)胞分化和骨形成過程中所必需的轉(zhuǎn)錄因子。骨髓基質(zhì)干細(xì)胞分化為表達(dá)典型的成骨性標(biāo)志基因的成骨細(xì)胞需要OSX的調(diào)控。