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胚胎干細(xì)胞抑制蛋白Suz12抗體
  • 產(chǎn)品貨號(hào)：
    BN42142R
  • 中文名稱：
    胚胎干細(xì)胞抑制蛋白Suz12抗體
  • 英文名稱：
    Rabbit anti-SUZ12 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42142R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,ICC,IF,ELISA

  • BN42142R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,ICC,IF,ELISA

產(chǎn)品描述

英文名稱SUZ12
中文名稱胚胎干細(xì)胞抑制蛋白Suz12抗體
別    名ChET 9 protein; Chromatin precipitated E2F target 9 protein; JJAZ1; Joined to JAZF1 protein; KIAA0160; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12; CHET9; Polycomb protein SUZ12; hET 9 protein; SUZ12_HUMAN; CHET9.  
研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
克 隆 號(hào)3C1
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:1000-2000 ELISA=1:5000-10000 IP=1:20-100 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量83kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human SUZ12: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹UZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.
SUZ12 is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2. SUZ12 mRNA is upregulated in a number of tumors including breast and colon.

Function:
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Subunit:
Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77. Interacts with histone H1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Overexpressed in breast and colon cancer.

DISEASE:
Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.

Similarity:
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Contains 1 C2H2-type zinc finger.

SWISS:
Q15022

Gene ID:
23512

Database links:

Entrez Gene: 23512 Human

Entrez Gene: 52615 Mouse

Omim: 606245 Human

SwissProt: Q15022 Human

SwissProt: Q80U70 Mouse

Unigene: 462732 Human

Unigene: 283410 Mouse

Unigene: 473315 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.






















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