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整合素α2重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42140R
  • 中文名稱：
    整合素α2重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Integrin alpha 2 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42140R-50ul

    50ul

    ￥2020.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF

  • BN42140R-100ul

    100ul

    ￥3240.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱Integrin alpha 2
中文名稱整合素α2重組兔單克隆抗體
別    名Integrin alpha 2; CD49b antigen; BR; CD 49b; CD49 antigen like family member B; CD49b; CD49b; Collagen receptor; DX5; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency, included; GPIa; HPA 5 included; HPA5 included; Itga2; Platelet alloantigen Br(a), included; Platelet antigen Br; Platelet glycoprotein GPIa; Platelet glycoprotein Ia; Platelet glycoprotein Ia/Iia; Platelet membrane glycoprotein Ia; Platelet receptor for collagen, deficiency of, included; Very late activation protein 2 receptor alpha 2 subunit; VLA 2 alpha chain; VLA 2; VLA 2 subunit alpha; VLA2 alpha chain; ITA2_HUMAN.  
研究領域腫瘤  細胞生物  細胞粘附分子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號14D7
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量127kDa
細胞定位細胞膜 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原Recombinant human Integrin alpha 2: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Function:
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

SWISS:
P17301

Gene ID:
3673

Database links:

Entrez Gene: 3673 Human

Entrez Gene: 16398 Mouse

Omim: 192974 Human

SwissProt: P17301 Human

SwissProt: Q62469 Mouse

Unigene: 482077 Human

Unigene: 5007 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.