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腦源神經(jīng)營養(yǎng)因子重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42129R
  • 中文名稱：
    腦源神經(jīng)營養(yǎng)因子重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti- BDNF Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN42129R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Zebrafish) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42129R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Zebrafish) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱BDNF
中文名稱腦源神經(jīng)營養(yǎng)因子重組兔單克隆抗體
別    名Abrineurin; Brain Derived Neurotrophic Factor; MGC34632; Neurotrophin; BDNF_HUMAN.  
研究領(lǐng)域神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號2A1
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Zebrafish, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
細胞定位細胞核 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BDNF: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. More recently, three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4), also designated NT-5. These various neurotrophins stimulate the in vitro survival of distinct but partially overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds equally well to both BDNF and NT-4 and to a lesser extent NT-3, while the Trk C receptor only binds NT-3. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Belongs to the NGF-beta family.

Function:
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Subunit:
Monomers and homodimers. Binds to NTRK2/TRKB.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

Post-translational modifications:
The propeptide is N-glycosylated and glycosulfated.
Converted into mature BDNF by plasmin (PLG).

DISEASE:
Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.

Similarity:
Belongs to the NGF-beta family.

SWISS:
P23560

Gene ID:
627

Database links:

Entrez Gene: 627 Human

Entrez Gene: 12064 Mouse

Entrez Gene: 24225 Rat

Omim: 113505 Human

SwissProt: P23560 Human

SwissProt: P21237 Mouse

SwissProt: P23363 Rat

Unigene: 502182 Human

Unigene: 1442 Mouse

Unigene: 11266 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.






















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